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. 2013 Feb 20;3:17–25. doi: 10.1016/j.rinim.2013.02.002

Fig. 1.

Fig. 1

The response to poly(I:C) and LPS is impaired in the Ii KO and M1 KO mice. (A) Splenocytes from C57BL/6, Ii KO and Xid mice were isolated and treated ex vivo for 24 h with LPS prior to RNA extraction and qPCR analysis of TNFα mRNA expression. (B) Splenocytes from C57BL/6, Ii KO and M1 KO mice were isolated and treated ex vivo for 24 h with either LPS or poly(I:C) prior to RNA extraction and qPCR analysis of TNFα mRNA expression. Expression is illustrated as fold level compared to the value of untreated C57BL/6 cells, which was set at 1. Data is representative of at least two different experiments.