TABLE 5.

Echocardiographic data of WT and αMHC-ARIA-Tg mice on either sham- or DOX-treatment

FS, fractional shortening; IVST, interventricular septal thickness; LVPW, left ventricular posterior wall thickness. n = 8 each.

	LVDd	LVDs	FS	IVST	LVPW
	mm	mm	%	mm	mm
WT sham	3.83 ± 0.34	2.59 ± 0.26	32.3 ± 3.6	0.69 ± 0.032	0.69 ± 0.043
αMHC-ARIA-Tg sham	3.84 ± 0.13	2.65 ± 0.13	31.2 ± 1.8	0.69 ± 0.041	0.70 ± 0.053
WT DOX	4.05 ± 0.31	3.01 ± 0.27a	25.7 ± 2.8a	0.63 ± 0.036a	0.61 ± 0.041a
αMHC-ARIA-Tg DOX	4.01 ± 0.21	3.14 ± 0.19b	21.7 ± 1.5b,c	0.60 ± 0.025b,d	0.58 ± 0.020b.d

^a p < 0.01 versus WT sham.

^b p < 0.01 versus αMHC-ARIA-Tg sham.

^c p < 0.01 versus WT DOX.

^d p < 0.05 versus WT DOX.