TABLE 7.

Echocardiographic data of dnPI3K-Tg, ARIA-KO, and dnPI3K-Tg/ARIA-KO mice on either sham or DOX treatment

FS, fractional shortening; IVST, interventricular septal thickness; LVPW, left ventricular posterior wall thickness. n = 5–6 each.

	LVDd	LVDs	FS	IVST	LVPW
	mm	mm	%	mm	mm
dnPI3K-Tg sham	3.82 ± 0.25	2.63 ± 0.18	31.1 ± 1.9	0.64 ± 0.021	0.64 ± 0.033
ARIA-KO sham	3.68 ± 0.18	2.50 ± 0.16	32.1 ± 2.4	0.70 ± 0.048	0.70 ± 0.036
dnPI3K-Tg/ARIA-KO sham	3.71 ± 0.23	2.57 ± 0.16	30.8 ± 0.88	0.67 ± 0.073	0.66 ± 0.018
dnPI3K-Tg DOX	3.92 ± 0.18	3.10 ± 0.19a,b	21.0 ± 1.7a,b	0.57 ± 0.055bc	0.58 ± 0.050b,c
ARIA-KO DOX	3.59 ± 0.24	2.51 ± 0.28	30.3 ± 4.5	0.65 ± 0.020	0.67 ± 0.007
dnPI3K-Tg/ARIA-KO DOX	3.86 ± 0.35	2.95 ± 0.29b,d,e	23.7 ± 2.7b,d,e	0.56 ± 0.067b,d,e	0.58 ± 0.087b,d,e

^a p < 0.01 versus dnPI3K-Tg sham

^b p < 0.01 versus ARIA-KO DOX

^c p < 0.05 versus dnPI3K-Tg sham.

^d p < 0.01 versus dnPI3K-Tg/ARIA-KO sham.

^e Not significant versus dnPI3K-Tg DOX.