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Model of dNTP-dependent allosteric regulation of EF1143 catalysis. dGTP binds to each of four primary allosteric sites (Intermediate). Binding of either dTTP or dGTP at the two secondary allosteric sites, adjacent to the primary site, results in an inhibited form, by closing the catalytic site (X), whereas binding of dATP or dCTP at the same secondary sites activates the enzyme (O).
