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Bioenergetics and mitochondrial content of GCN5L1 MEFs. A and B, mitochondrial bioenergetic profile of GCN5L1 MEFs. Knock-out cells are defective in maximal respiration capacity and ATP synthesis. C and D, mitochondrial energetic defects in GCN5L1 knock-out cells are complemented by an increase in glycolysis. E–G, there is no significant difference in mitochondrial protein levels, mtDNA copy number or mitochondrial volume between wild type and knock-out cells.
