Figure 1. Comparison of the phenotypic and functional characteristics of putative EPC determined by different assays.
The cells isolated by the CFU-Hill and CAC assays identify essentially similar proangiogenic hematopoietic subsets. In contrast the cells isolated in the ECFC assay differ from the proangiogenic cells by displaying clonal proliferative potential, replating ability, and in vivo vessel forming ability. In addition the phenotype of the ECFC can be distinguished from the proangiogenic cells by the lack of CD133, CD45, and CD115 expression by the ECFC. Abbreviations: ALDH: aldehyde dehydrogenase, acLDL: acetylated low density lipoprotein, VEGFR2: vascular endothelial growth factor receptor 2.