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. Author manuscript; available in PMC: 2014 Jan 31.
Published in final edited form as: Pharmacol Res. 2011 Jul 8;65(1):41–47. doi: 10.1016/j.phrs.2011.07.002

Figure 6. Relaxation responses to the nitroxyl anion donor, Angeli’s Salt, are mediated through soluble guanylate cyclase.

Figure 6

Concentration response curves to AS were performed in Phe (1 µM) contracted aorta from AngII (AngII) and sham (Sham) in the presence of the (a) voltage-gated potassium channel blocker, 4-AP (100 mM) and the (b) soluble guanylate cyclase inhibitor, ODQ (1 µM). Data are represented as mean ± SEM; n=5–8. ‡p<0.0001, EC50 values of 4-AP vs. vehicle in AngII, ‡p<0.0001, Rmax values of ODQ vs. vehicle in sham and AngII.