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. Author manuscript; available in PMC: 2014 Jan 31.
Published in final edited form as: Int J Cancer. 2008 Jun 1;122(11):2462–2470. doi: 10.1002/ijc.23383

Figure 5.

Figure 5

Oncogenic K-ras differentially regulates PKCβII expression in the proximal and distal colon. (a) Immunoblot analysis of PKCβII protein expression in colonic epithelium isolated from the distal and proximal colon of 2 LSL-K-rasG12D mice (LSL) and 2 LSL-K-rasG12D/Vil-Cre/+ mice (LSL/cre). Actin protein levels are shown as a loading control. Immunoblot results are representative of 3 independent experiments. (b) PKCβII mRNA abundance was determined by qRT-PCR analysis of mRNA isolated from the colonic epithelium of LSL and LSL/cre mice. RNA abundance was normalized to GAPDH. Values represent mean ± SEM; n = 3–6.