Figure 6.
Oncogenic K-ras- and AOM-induced ACF distribute differently Throughout the Colon. K-rasLA2 mice treated with saline (sal) or AOM (AOM) were examined for ACF number and distribution (see Material and Methods for details). (a) Number of ACF in the total colon, distal colon and proximal colon is plotted as a box plot (first quartile, median and third quartile are illustrated). (b–d) The number of (b) small ACF (1–5 aberrant crypts/foci), (c) large ACF (6–10 aberrant crypts/foci) and (d) microadenoma (>10 aberrant crypts/foci) in the proximal colon of saline and AOM-treated K-rasLA2 mice is plotted. n = 6 mice/group.
