Transplanting CD11b− donor APCs lead to increased IFN-γ production by donor T cells. A–C, Mean numbers (±SD) of cytokine producing CD4 (top) and CD8 (bottom) T cells were determined per spleen. A, IFN-γ+ donor T cells; B, IL-4+ donor T cells; C, IL-10+ donor T cells. D, Th1 (top) and Th2 (bottom) cytokine concentrations determined in serum of recipients 3 and 10 days posttransplant. Data are from three experiments with a total of nine mice at each time point per group. p values are based on comparisons of cytokine levels from mice that received donor APCs with those that received HSCs and T cells. *, p < 0.05; **, p < 0.01; ***, p < 0.001.