Figure 1.

The lowest energy conformations of (A) (R,R′)-2, (B) (R,R′)-64 and (C) (R,S′)-64 obtained in docking simulations to molecular model of β₂-AR binding site. For clarity of both figures, TM1, TM2, and extracellular loop 2 were hidden, and the remaining transmembrane segments are color coded as follows: TM3, red; TM4, green; TM5, magenta; TM6, yellow; and TM7, blue. Only the residues forming hydrogen bonds (shown as green arrows) with a ligand molecule are shown explicitly. All aliphatic hydrogen atoms are hidden.