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. 2013 Oct 22;35(2):489–496. doi: 10.1093/carcin/bgt350

Fig. 2.

Fig. 2.

Cervical diseases are absent in K14E7/ERα N/− mice. (A) Mice of indicated genotypes were treated with E2 for 6 months. Representative images of hematoxylin and eosin-stained cervical sections are shown. White arrowhead indicates an invading carcinoma and arrows point to epithelia. Scale bar, 100 μm. (B) Cervical epithelial cell proliferation is greatly reduced in K14E7/ERα N/− mice. Cervical sections were stained for Ki67 (brown nuclei staining) and nuclei were counterstained with hematoxylin. Scale bar, 50 μm. (C) Results shown in B are quantified and displayed as mean ± standard error of the mean (n = 3), *P = 0.02. (D) ASM is absent in K14E7/ERα N/− mice. Representative images of hematoxylin and eosin-stained cervical transformation zone are shown. White and black arrowheads point to squamous and columnar epithelium, respectively. Note that squamous epithelia are embedded in columnar epithelium in K14E7/ERα +/− mice but not in K14E7/ERα N/− mice. ASM incidence is indicated in the lower right corner of each image. Scale bar, 100 μm.