Table V.
Urinary levels of mercapturic acid metabolites of volatile organic compounds in relation to lung cancer risk among lifelong never smokers, the Shanghai Cohort Study 1986–2008
| Urinary mercapturic acid metabolites | Quartile of biomarker | P for trend | |||
|---|---|---|---|---|---|
| First (lowest) | Second | Third | Fourth (highest) | ||
| HPMA | |||||
| Casesa | 21 | 19 | 19 | 21 | |
| Controlsa | 21 | 20 | 21 | 20 | |
| OR (95% CI)b | 1.00 | 0.97 (0.40–2.34) | 0.98 (0.40–2.36) | 1.13 (0.47–2.75) | 0.79 |
| SPMA | |||||
| Casesa | 17 | 18 | 19 | 26 | |
| Controlsa | 21 | 20 | 21 | 20 | |
| OR (95% CI)b | 1.00 | 1.03 (0.39–2.69) | 1.10 (0.44–2.78) | 1.57 (0.65–3.80) | 0.31 |
| HMPMA | |||||
| Casesa | 24 | 17 | 19 | 20 | |
| Controlsa | 21 | 20 | 21 | 20 | |
| OR (95% CI)b | 1.00 | 0.75 (0.31–1.83) | 0.80 (0.33–1.97) | 1.00 (0.41–2.41) | 0.99 |
| HEMA | |||||
| Casesa | 24 | 21 | 19 | 16 | |
| Controlsa | 21 | 20 | 21 | 20 | |
| OR (95% CI)b | 1.00 | 1.02 (0.43–2.43) | 0.86 (0.36–2.06) | 0.75 (0.31–1.85) | 0.49 |
aTwo cases and one control subjects with missing value of urinary mercapturic acids were excluded from the analysis.
bAdjusted for age at baseline, neighborhood of residence at enrollment, years of sample storage and urinary cotinine level.