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. 2014 Jan 24;9:695–710. doi: 10.2147/IJN.S55255

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© 2014 Cheng et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Response surface plots of CCD.

Notes: (A) Response surface plots of mean particle size (Y₁), X₁= CTS/TPP; X₂= 5-FU/CTS; TPP concentrations (%, w/v). (B) Response surface plots of drug content (Y₂), X₁= CTS/TPP; X₂= 5-Fu/CTS; TPP concentrations (%, w/v). (C) Response surface plots of total desirability function, X₁= CTS/TPP; X₂= 5-FU/CTS; TPP concentrations (%, w/v); X₄= crosslinking time (minutes).

Abbreviations: 5-FU, 5-fluorouracil; CCD, central composite design; CTS, chitosan; TPP, tripolyphosphate sodium; w/v, weight per volume.