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. 2014 Jan 24;9:695–710. doi: 10.2147/IJN.S55255

Figure 3.

Figure 3

Scanning electron microscopy of nanoparticles; their protective effect on drugs in vitro.

Notes: (A) Suspension, electron micrograph, and particle size of CTS/5-FU nanoparticles. (B) Suspension, electron micrograph, and particle size of GA-CTS/5-FU nanoparticles. (C) Electron micrograph and particle size of GA-CTS/5-FU nanoparticles mixed with fetal bovine serum. (D) Electropherogram of GA-CTS/plasmid DNA nanoparticles with DNase I and fetal bovine serum. Lane 1: naked plasmid DNA digested with bovine serum at 37°C for 8 hours. Lane 2: naked plasmid DNA digested with DNase l at 37°C for 30 minutes. Lane 3: naked plasmid DNA without any treatment. Lane M: marker 5,000 (5,000, 3,000, 1,500, 1,000, 750, 500, 250, 100, and 50 bp ordered reading top to bottom). Lanes 4–6: GA-CTS/plasmid DNA digested with DNase l at 37°C for 30 minutes, 1 hour, and 1.5 hours. Lane 7: GA-CTS/plasmid DNA digested with DNase l at 37°C for 8 hours. Lane 8: GA-CTS/plasmid DNA digested with bovine serum at 37°C for 8 hours. Lane 9: GA-CTS nanoparticles without any treatment.

Abbreviations: 5-FU, 5-fluorouracil; CTS, chitosan; GA-CTS, glycyrrhetinic acid-modified chitosan; NPs, nanoparticles.