Figure 5.
PAR-4 (LKB1) is necessary and sufficient for dendrite outgrowth. (a, b) Lateral view of wild-type and par-4 mutants expressing Pmig-13:: mig-13::gfp at L3 stage. (c) Graph of dendrite length in L3 wild-type, par-4, par-4 rescue (par-4(it47); Ex[Pitr-1::par-4::gfp]) and par-4 overexpression (Ex[Pitr-1::par-4::gfp]). All worms are L3 stage, all pictures are lateral view with ventral down and anterior to the left, all quantification from anterior edge of soma to anterior tip of dendrite. Scale bar, 20 μm. n ≥ 30. Error bars, s.e.m. ***P < 0.001; NS, not significant; Student’s t-test.