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. Author manuscript; available in PMC: 2014 Jan 31.
Published in final edited form as: Nat Neurosci. 2010 Dec 26;14(2):165–172. doi: 10.1038/nn.2717

Figure 7.

Figure 7

unc-34 and par-4 act in parallel in AVM development. (a) The AVM soma is located laterally in the worm and extends a process which first migrates ventrally, then anteriorly into the head (ventral down, anterior to the left). (b) unc-34 and unc-40 mutants show a guidance defect in which the AVM process fails to make a ventral turn before extending12. (c) Graph of percentage of guidance defects in AVM. Wild-type and par-4 single mutants do not show ventral guidance defects, whereas unc-34 mutants show a low-penetrance defect. The frequency is enhanced in unc-34; par-4 double mutants. (d) Graph of percentage of outgrowth defects in the AVM process. Wild-type, par-4 and unc-34 single mutants consistently have AVM processes that grow beyond the pharynx terminal bulb, whereas par-4, unc-34 double mutants show a low-penetrance outgrowth defect. n ≥ 100. Error bars, standard error of proportion; **P < 0.01, *P < 0.05, χ2 test.