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. Author manuscript; available in PMC: 2014 Jan 31.
Published in final edited form as: Curr Opin Hematol. 2009 Jul;16(4):249–254. doi: 10.1097/MOH.0b013e32832c4b80

Figure 1. Normal hematopoietic stem and progenitor cells migrate in and out from the bone marrow niches.

Figure 1

Rac1 controls proliferation, endosteal localization and engraftment, whereas Rac2 controls survival and bone marrow retention. Cdc42 controls endosteal localization, engraftment and retention as well as aging and self-renewal of HSC/Ps. HSC/Ps, hematopoietic stem and progenitor cells. Inline graphic stem cell; Inline graphic, hematopoietic progenitor; Inline graphic, migrating cell; Inline graphic, endosteal niche; Inline graphic, vascular niche.