Table S2.
Unit costs (2011 Canadian$)
| Cost item | Unit | 2011 Cost* | Source |
|---|---|---|---|
| Drugs | |||
| Daily ticagrelor | 90 mg twice daily | $2.96 | AstraZeneca Canada |
| Loading dose ticagrelor | 180 mg | $2.96 | AstraZeneca Canada |
| Loading dose clopidogrel | 300 mg | $10.31 (generic $2.58) | Ontario Drug Benefit Program3 |
| Daily clopidogrel | 75 mg once daily | $2.58 | Ontario Drug Benefit Program3 |
| Daily clopidogrel (generic) | 75 mg once daily | $0.645 | Calculated (25% of brand name) |
| Daily ASA | 75–150 mg | $0 | Equivalent between two groups |
| Hospitalizations | |||
| General ward, cardiac care unit, and coronary care ward | Per day | $1,612 | Ontario Case Costing Initiative1 Based on average cost per day for CCU for UA and MI (I200, I201, I2080, I2088, I209, and I219) |
| Intensive care unit | Per day | $3,932 | Ministry of Health and Long-Term Care4 |
| Interventions (physician fees) | |||
| CABG with valve replacement | Per operation | $7,396 | Ontario Schedule of Benefits5 |
| CABG without valve replacement | Per operation | $6,001 | Ontario Schedule of Benefits5 |
| Implantable cardiac defibrillator | Per procedure | $1,096 | Ontario Schedule of Benefits5 |
| Intra-aortic balloon pump | Per procedure | $312 | Ontario Schedule of Benefits5 |
| Left ventricular assist device | Per procedure | $2,817 | Ontario Schedule of Benefits5 |
| Pacemaker | |||
| Implantation of single chamber rate-responsive pacemaker | Per procedure | $487 | Ontario Schedule of Benefits5 |
| PCI without stent | Per procedure | $567 | Ontario Schedule of Benefits5 |
| PCI with stent | Per procedure | $647 | Ontario Schedule of Benefits5 |
| Bare metal stent | Per unit | $600 | Goeree et al6 |
| Drug-eluting stent | Per unit | $1,899 | Goeree et al6 |
| Investigations (physician fees) | |||
| Coronary angiography | Per procedure | $212 | Ontario Schedule of Benefits5 |
| CT abdomen | Per procedure | $115 | Ontario Schedule of Benefits5 |
| CT chest | Per procedure | $92 | Ontario Schedule of Benefits5 |
| CT extremity | |||
| CT, arm | Per procedure | Assumed all were leg | Ontario Schedule of Benefits5 |
| CT, leg | Per procedure | $81 | Ontario Schedule of Benefits5 |
| CT head/brain | |||
| CT, head | Per procedure | $81 | Ontario Schedule of Benefits5 |
| CT, brain | Per procedure | Assumed all were head | Ontario Schedule of Benefits5 |
| CT helical | Per procedure | Assumed the same as spine | Ontario Schedule of Benefits5 |
| CT spine | Per procedure | $115 | Ontario Schedule of Benefits5 |
| Echocardiography | Per procedure | $140 | Ontario Schedule of Benefits5 |
| Electrophysiology study | Per procedure | $1,608 | Ontario Schedule of Benefits5 |
| Holter study | Per procedure | $273 | Ontario Schedule of Benefits5 |
| MRI abdomen | Per procedure | $78 | Ontario Schedule of Benefits5 |
| MRI chest | Per procedure | $78 | Ontario Schedule of Benefits5 |
| MRI extremity | Per procedure | $67 | Ontario Schedule of Benefits5 |
| MRI, arm | Per procedure | Assumed same as CT extremity | Ontario Schedule of Benefits5 |
| MRI, leg | Per procedure | Assumed same as CT extremity | Ontario Schedule of Benefits5 |
| MRI head/brain | Per procedure | $74 | Ontario Schedule of Benefits5 |
| MRI, head | Per procedure | Assumed same as CT head/brain | Ontario Schedule of Benefits5 |
| MRI, brain | Per procedure | Assumed same as CT head/brain | Ontario Schedule of Benefits5 |
| MRI spine | Per procedure | $108 | Ontario Schedule of Benefits5 |
| Myocardial scintigraphy | Per procedure | $166 | Ontario Schedule of Benefits5 |
| Pulmonary angiography | Per procedure | $120 | Ontario Schedule of Benefits5 |
| Stress test | Per procedure | $98 | Ontario Schedule of Benefits5 |
| Ventilation/perfusion scan | Per procedure | $301 | Ontario Schedule of Benefits5 |
| Bleeds | |||
| Reoperation due to bleeding | Per operation | $694 | Ontario Schedule of Benefits5 |
| Unit of fresh frozen plasma | Per unit | $249 | Callum and Pinkerton7 |
| Unit of packed red blood cells | Per unit | $453 | Callum and Pinkerton7 |
| Unit of platelets | Per unit | $566 | Callum and Pinkerton7 |
| Unit of whole blood | Per unit | $453 | Callum and Pinkerton7 |
| Significant adverse events | |||
| Dyspnea | Physician visits | $35.40 * 2 = $70.80 | Ontario Schedule of Benefits5 |
Notes:
*
In some instances costs were inflated to 2011. All values are in Canadian dollars.
Abbreviations: ASA, acetylsalicylic acid; CABG, coronary artery bypass surgery; CCU, coronary care unit; CT, computed tomography; MI, myocardial infarction; MRI, magnetic resonance imaging; PCI, percutaneous coronary intervention; UA, unstable angina.