Table S5.
Output of one-way sensitivity analyses: incremental cost per QALY for ticagrelor versus clopidogrel
| Parameters | Low value | High value |
|---|---|---|
| Hazard ratio for ticagrelor versus clopidogrel for death from any cause within trial | $7,391 | $17,685 |
| Hazard ratio for ticagrelor versus clopidogrel for nonfatal MI within trial | $8,209 | $11,618 |
| Hazard ratio for ticagrelor versus clopidogrel for nonfatal stroke within trial | $8,465 | $11,479 |
| Probability of death from any cause within trial for clopidogrel | $10,467 | $9,120 |
| Probability of nonfatal MI within trial for clopidogrel | $9,927 | $9,564 |
| Probability of nonfatal stroke within trial for clopidogrel | $9,657 | $9,830 |
| Probability of dyspnea whilst on ticagrelor | $9,739 | $9,750 |
| Probability of dyspnea whilst on clopidogrel | $9,749 | $9,740 |
| Cost associated with no event state in Markov model | $9,090 | $10,398 |
| Cost associated with post-MI state in Markov model | $9,865 | $9,624 |
| Cost associated with post-stroke state in Markov model | $9,628 | $9,861 |
| Cost associated with nonfatal MI state in Markov model | $9,632 | $9,857 |
| Cost associated with nonfatal stroke state in Markov model | $9,688 | $9,801 |
| Cost of dyspnea in primary care | $9,719 | $9,770 |
| Cost of brand clopidogrel | – | $1,523 |
| Cost of generic clopidogrel (20% brand price) | – | $10,293 |
| Utility accrued in no event in decision tree | $9,753 | $9,736 |
| Utility accrued in death any cause in decision tree | $9,708 | $9,782 |
| Utility accrued in nonfatal MI in decision tree | $9,728 | $9,761 |
| Utility accrued in nonfatal stroke in decision tree | $9,751 | $9,738 |
| Utility associated with no event state in Markov model | $9,962 | $9,536 |
| Utility associated with nonfatal MI state in Markov model | $9,746 | $9,743 |
| Utility associated with nonfatal stroke state in Markov model | $9,757 | $9,732 |
| Utility associated with post-MI state in Markov model | $9,709 | $9,780 |
| Utility associated with post-stroke state in Markov model | $9,839 | $9,651 |
| Utility associated with dyspnea (utility reduced by 7% for 7 days9) | – | $9,849 |
Note: All values are in Canadian dollars.
Abbreviations: MI, myocardial infarction; QALY, quality-adjusted life year.