Table S3.

Values used in one-way sensitivity analysis

Variable	Parameter	Range		Source
		Low	High
Event rates for clopidogrel (1-year decision tree)
Dead any cause	0.0545	0.0500	0.0590	95% confidence intervals based on PLATO data
Nonfatal MI	0.0522	0.0477	0.0567
Nonfatal stroke	0.0080	0.0062	0.0097
Hazard ratios for ticagrelor versus clopidogrel (1-year decision tree)
Dead any cause	0.78	0.69	0.89	95% confidence intervals based on PLATO data
Nonfatal MI	0.86	0.76	0.98
Nonfatal stroke	1.09	0.80	1.49
Utilities from PLATO study
No further event	0.875	0.871	0.879	95% confidence intervals based on PLATO HECON substudy
New MI	0.812	0.792	0.832
New stroke	0.736	0.662	0.810
Dead any cause	0.249	0.222	0.276
New MI (mm)	0.812	0.792	0.832
Post-MI/no event (mm)	0.854	0.834	0.873
New stroke (mm)	0.736	0.662	0.810
Post-stroke (mm)	0.736	0.662	0.810
Resource cost for the Markov model
New MI	$10,824	$8,659	$12,989	Costs were varied by ±20%
Post-MI/no event	$3,112	$2,490	$3,734
New stroke	$20,823	$16,658	$24,988
Post-stroke	$4,336	$3,469	$5,203

Note: All values are in Canadian dollars.

Abbreviations: MI, myocardial infarction; PLATO, Platelet Inhibition and Patient Outcomes.