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. Author manuscript; available in PMC: 2014 Jan 31.
Published in final edited form as: Synapse. 2011 Mar 21;65(8):771–777. doi: 10.1002/syn.20902

Figure 2.

Figure 2

Rats were treated identically as described in the legend to Fig. 1 except that rats received the 4-injection METH regimen in a warm environment (25 °C). Rats were decapitated 1 hour (panels A and B) or 7 days (panels C and D) later. The warm environment resulted in similar core body temperatures in rats given the 4-injection METH regimen regardless of the pretreatment given during development (panels B and D) and similar reductions in vesicular uptake (panels A and C). *Values for saline pretreated/METH challenged (saline/METH) and METH pretreated/METH challenged (METH/METH) rats are significantly different from METH pretreated/saline challenged controls (METH/saline) and saline pretreated/saline challenged controls (saline/saline; p < 0.05). #Values for the saline/METH group significantly differ from all other groups (p < 0.05). Data are expressed as means ± SEM.