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. 2014 Jan 31;9(1):e86491. doi: 10.1371/journal.pone.0086491

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© 2014 Hosokawa et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The inhibitory effects of dabigatran (Dabi) and rivaroxaban (Riva) on thrombin generation (TG) in platelet-rich plasma in the absence (panel A) and presence of 100 µM aspirin (Asp) together with 1 µM AR-C66096 (AR-C) (panel B) were calculated using Thrombinoscope™. Typical TG patterns obtained in one of the experiments are shown.