Table 1. Prescription and over the counter drugs that can activate the pregnane X receptor (PXR) (selection).

PXR ligands	Examples
Androgen receptor antagonists	Cyproterone acetate
Antiepileptics	Phenytoin, carbamazepine
Antiestrogens	Tamoxifen
Antihypertensives	Nifedipine, spironolactone
Antimycotics	Clotrimazole
Antiretroviral drugs (NNRTI/protease inhibitors)	Efavirenz, nevirapine / ritononavir, saquinavir
Antituberculosis drugs	Rifampicin
Glucocorticoids	Dexamethasone
Phytopharmaceuticals	Kava-kava, St. John’s wort (hyperforin)
Cytostatics	Cyclophosphamide, paclitaxel