Table 3. Intravascular volume parameters.

	Solvent	12 µM	100 µM	∑ NS1619	Solv. vs.∑ NS1619	Solvent	12 µM	100 µM	∑ NS1619	Solv. vs.∑ NS1619
rSVV	+0,00±0,01	−0,03±0,04	−0,01±0,02	−0,02±0,02	P = 0,44	+0,02±0,02	+0,01±0,03	−0,04±0,02	+0,02±0,02	P = 0,18
SPV	−0,01±0,02	+0,03±0,04	+0,01±0,01	+0,02±0,02	P = 0,31	+0,02±0,02	+0,05±0,03	+0,01±0,01	+0,03±0,02	P = 0,76
rSV (mmHg* s)	+0,04±0,52	+2,93±3,02	−0,22±0,74	+1,35±1,56	P = 0,50	+0,49±1,20	−0,58±0,97	+0,28±1,42	−0,15±0,84	P = 0,66
PPV	+0,01±0,01	+0,08±0,08	−0,01±0,01	+0,04±0,04	P = 0,38	+0,03±0,03	+0,09±0,04	−0,00±0,02	+0,05±0,03	P = 0,72
	(Δ) 30 min after inhalation					(Δ) 120 min after inhalation

For the investigation of fluid responsive parameters were calculated: relative stroke volume (rSV) characterized by the area under the arterial blood pressure curve, systolic pressure variation (SPV), relative stroke volume variation (rSVV), and pulse pressure variation (PPV). No NS1619-dependent effect on these parameters was discovered. Data obtained after inhalation were subtracted from individual basis values and individual value differences (Δ) were calculated for each animal and time point.