Table 5.
Pathway analysis of the selected miRNAs
| KEGG_Description | Target genes | P -value |
|---|---|---|
| miR-1 |
|
|
| hsa3040: Spliceosome |
ISY1 DDX5 SFRS9 DHX15 HNRNPU TRA2B SFRS1 HNRNPA3 HNRNPK SFRS3 |
1.39E-03 |
| hsa4320: Dorso-ventral axis formation |
NOTCH2 EGFR NOTCH3 CPEB1 ETS1 |
3.86E-03 |
| miR-26a-5p |
|
|
| hsa4115: p53 signaling pathway |
CCNE2 CCNE1 PTEN CDK6 CCND2 IGF1 ATM |
1.98E-03 |
| hsa4010: MAPK signaling pathway |
TGFBR2 MYC PPP3R1 CACNA1C PPP3CB MAP3K1 NLK PAK2 |
8.40E-03 |
| miR-466 |
|
|
| hsa4150: mTOR signaling pathway |
PRKAA2 RPS6KA3 EIF4E ULK2 RICTOR |
2.36E-03 |
| hsa5200: Pathways in cancer |
CCDC6 ARNT2 KIT CYCS COL4A1 GLI3 PTGS2 SMAD2 RUNX1T1 TGFB2 TCF7L2 DAPK1 MECOM |
4.56E-03 |
| miR-574-3p |
|
|
| hsa5200: Pathways in cancer |
CUL2 EP300 ACVR1B RXRA |
3.75E-03 |
| hsa5016: Huntington's disease |
EP300 CLTC |
4.38E-03 |
| hsa5211: Renal cell carcinoma |
CUL2 EP300 |
9.33E-03 |
| miR-3613-3p |
|
|
| hsa4520: Adherens junction |
TCF7 EP300 CREBBP ACTN4 FGFR1 PTPRJ INSR TCF7L2 ACVR1C IGF1R CTNNB1 CTNND1 WASL LMO7 SMAD4 |
5.19E-06 |
| hsa4310: Wnt signaling pathway |
NFATC3 TCF7 NFAT5 EP300 CREBBP AXIN2 GSK3B PPP3CA VANGL2 TCF7L2 PPP2R5A WNT5A CCND2 PPP3R1 CCND1 CTNNB1 CSNK1A1 CSNK1E WNT4 SMAD4 |
9.31E-05 |
| hsa4720: Long-term potentiation |
EP300 CREBBP PPP1R12A PPP3CA PPP1CB PPP3R1 RPS6KA2 RAP1A GRIA1 KRAS |
6.75E-04 |
| hsa4330: Notch signaling pathway |
JAG1 EP300 MAML3 CREBBP ADAM17 DLL1 NUMBL HDAC2 |
2.88E-03 |
| hsa4910: Insulin signaling pathway |
PRKCI PPP1R3B PPARGC1A ACACB GSK3B PRKAA1 INSR SOCS3 IRS1 EIF4E PPP1CB KRAS IRS2 |
6.80E-03 |
| hsa4920: Adipocytokine signaling pathway | PPARGC1A ACACB PRKAA1 SOCS3 IRS1 STAT3 ACSL4 ACSL6 IRS2 | 8.20E-03 |