Table 2. Amino acid substitutions detected in the RT-encoding region of RT-SHIV isolated from rhesus macaques at 4 and 30 weeks post-inoculation.
| Week 4 | Week 30 | |||||
| Animal | Plasmaa | PBMCb | Plasmaa | PBMCb | Plasmac | Virus loadd |
| 33717 | G196R | G196R | e | f | f | Undetectable |
| K275R | K275R | |||||
| 33704 | G196R | T69N | – g | – | f | Moderate |
| E79K | ||||||
| G196R | ||||||
| 33753 | G196R | G196R | G196R | G196R | f | Moderate |
| Q507H | ||||||
| 33731 | G196G/R | – | V75L | V75L | V75L | High |
| G196R | G196R | G196R | ||||
| L214F | L214F | L214F | ||||
| K275R | K275R | K275R | ||||
| M357T | M357T | M357T | ||||
| Q507H | Q507H | Q507H | ||||
| 33741 | G196R | K275R | V75L | L74V | V75L | High |
| G196R | G196R | G196R | ||||
| L214F | L214F | L214F | ||||
| K275R | K275R | K275R | ||||
| K558R | ||||||
| 33810 | – | – | V75L | V75L | V75L | High |
| L214F | L214F | L214F | ||||
| Q507H | M357R | M357R | ||||
| Q507H | Q507H | |||||
| H208L | R277K | |||||
| T286A | ||||||
| 33917 | G196R | – | L74V | L74V | L74V | High |
| K103N | K103N | K103N | ||||
| G196R | G196R | G196R | ||||
| P225H | P225H | P225H | ||||
| V108I | ||||||
| E203K | ||||||
a
Plasma viral RNA.
b
PBMC co-culture proviral DNA.
c
Plasma co-culture proviral DNA.
d
Relative virus load at week 30.
e
No detectable viral RNA.
f
No virus isolated.
g
Wild-type virus.