Table 3. Amino acid substitutions detected in Env (gp120 and gp41) of RT-SHIV isolated from rhesus macaques at 4 and 30 weeks post-inoculation.
| Week 4 | Week 30 | |||||
| Envelope | gp120 | gp41 | ||||
| Animal | PBMCa | PBMCa | Plasmab | PBMCa | Plasmab | Virus loadc |
| 33717 | N405K | d | d | d | d | Undetectable |
| 33704 | – e | V67M R435K | d | R751G L802F R813QV837A L852I | d | Moderate |
| 33753 | R751G Q835R | I40V R120K T136A A417V | d | P741L R751G R813QA848V | d | Moderate |
| 33731 | – | V67L D511G | V67L D511G K125ET136M Δ421–426 | R751G V837G | I702V R751G V837G | High |
| 33741 | R751G | L4P V67M Q164H A417T P421S D511G | V67M S116N A138TK141E Q164H T173SK355R A417T P421S | S627K R751G | S627K R751G | High |
| 33810 | L24Q | G62D V67M W345R P421T D511G Δ415–420 | G62D V67M S135PW345R G347E D511NΔ415–421 | V562L R751G | M543I V562L R751G | High |
| 33917 | R751G | V67M N523S Δ415–420f | V67M D511G N523SΔ135–137 Δ423–426 | R751G | K631E R751G | High |
a
PBMC co-culture proviral DNA.
b
Plasma co-culture proviral DNA.
c
Relative virus load at week 30.
d
No virus isolated from plasma at week 30.
e
Wild-type virus.
f
“Δ” notation represents a deletion at the specified residues.