Table 2. Distribution of Age-Related Macular Degeneration Genetic Variants Among Progressors and Non-Progressors.
| Gene/Genotype | Progression | Gene/Genotype | Progression | ||||||
| Yes | No | p-value* | Yes | No | p-value* | ||||
| Total patients N (%) | 777 (28.1) | 1988 (71.9) | 777 (28.1) | 1988 (71.9) | |||||
| CFH(Y402H) | TT | 123 (16) | 723 (36) | <0.0001 | LIPC | CC | 420 (54) | 1036 (52) | 0.25 |
| CT | 343 (44) | 922 (46) | CT | 308 (40) | 805 (40) | ||||
| CC | 311 (40) | 343 (17) | TT | 49 (6) | 147 (7) | ||||
| CFH | TT | 29 (4) | 329 (17) | <0.0001 | ABCA1 | CC | 443 (57) | 1094 (55) | 0.28 |
| CT | 231 (30) | 903 (45) | CT | 290 (37) | 765 (38) | ||||
| CC | 517 (66) | 756 (38) | TT | 44 (6) | 129 (6) | ||||
| ARMS2/HTRA1(A69S) | GG | 244 (31) | 1164 (59) | <0.0001 | FRK/COL10A1 | CC | 401 (52) | 1046 (53) | 0.73 |
| GT | 368 (47) | 701 (35) | CT | 315 (41) | 784 (40) | ||||
| TT | 165 (21) | 123 (6) | TT | 60 (8) | 155 (8) | ||||
| C2 (E318D) | GG | 748 (96) | 1827 (92) | <0.0001 | APOC1/APOE | AA | 568 (73) | 1422 (72) | 0.41 |
| CG/CC | 29 (4) | 161 (8) | AG/GG | 209 (27) | 566 (28) | ||||
| CFB (R32Q) | CC | 715 (93) | 1615 (84) | <0.0001 | TIMP3 | AA | 712 (92) | 1774 (89) | 0.06 |
| CT/TT | 56 (7) | 318 (16) | AC/CC | 65 (8) | 214 (11) | ||||
| C3 (R102G) | CC | 386 (50) | 1234 (62) | <0.0001 | TNFRSF10A | TT | 222 (29) | 540 (27) | 0.87 |
| CG | 318 (41) | 669 (34) | GT | 373 (48) | 1020 (51) | ||||
| GG | 73 (9) | 84 (4) | GG | 182 (23) | 428 (22) | ||||
| CFI | CC | 181 (23) | 526 (26) | 0.01 | ADAMTS9/AS2 ** | CC | 241 (31) | 581 (29) | 0.27 |
| CT | 373 (48) | 983 (50) | CT | 375 (48) | 964 (48) | ||||
| TT | 223 (29) | 479 (24) | TT | 161 (21) | 443 (22) | ||||
| CETP | CC | 310 (40) | 880 (44) | 0.003 | SLC16A8 | CC | 493 (64) | 1267 (64) | 0.46 |
| AC | 356 (46) | 902 (45) | CT | 241 (31) | 641 (32) | ||||
| AA | 111 (14) | 205 (10) | TT | 43 (6) | 80 (4) | ||||
| COL8A1 | TT | 594 (76) | 1636 (82) | 0.0004 | DDR1 | CC | 546 (70) | 1394 (70) | 0.59 |
| CT | 170 (22) | 332 (17) | CT | 218 (28) | 540 (27) | ||||
| CC | 13 (2) | 20 (1) | TT | 13 (2) | 54 (3) | ||||
| COL10A1 | AA | 292 (38) | 715 (36) | 0.06 | TGFBR1 | TT | 463 (60) | 1137 (57) | 0.20 |
| AG | 379 (49) | 921 (46) | GT | 271 (35) | 722 (36) | ||||
| GG | 106 (14) | 351 (18) | GG | 43 (6) | 129 (6) | ||||
| CFH R1210C | CC | 769 (99) | 1982 (99.7) | 0.02 | VEGFA | CC | 150 (19) | 451 (23) | 0.06 |
| CT | 8 (1) | 6 (0.3) | CT | 399 (51) | 996 (50) | ||||
| RAD51B | AA | 331 (43) | 791 (40) | 0.02 | TT | 228 (29) | 540 (27) | ||
| AG | 367 (47) | 914 (46) | HSPH1/B3GALTL | TT | 232 (30) | 666 (34) | 0.006 | ||
| GG | 79 (10) | 283 (14) | CT | 369 (47) | 963 (48) | ||||
| HSPH1/B3GALTL | TT | 232 (30) | 666 (34) | 0.006 | CC | 176 (23) | 359 (18) | ||
| CT | 369 (47) | 963 (48) | |||||||
| CC | 176 (23) | 359 (18) | |||||||
*
Mantel-Haenszel Chi-Square.
**
ADAMTS9/ADAMTS9-AS2.