Figure 4. A model showing the possible interactions between RNAi pathways and MIR846, AT5G28520 and ABA in roots. A variant of miR846 is normally expressed that directs the post-transcriptional cleavage/repression of AT5G28520 in the absence of ABA; ABA induces the expression of AT5G28520 transcriptionally and simultaneously represses miR846 by directing alternative pri-miR846 splicing (Δ = change) and possibly modulating biogenesis through RNAi effectors known to impact ABA sensitivity by unknown mechanisms. AGO1 and DCL1 are known to act downstream of pre-miR846 hairpin biogenesis. Transcriptional repression (Δ) of MIR846 by ABA may also be involved.