Table 1. Distribution of major HLA-DPB1 alleles in Chinese controls and SSc patients.
Control | % | SSc | % | p | OR (95% CI) | |
DPB1*02:01 | 187 | 19.48 | 95 | 14.05 | 0.0042 | 0.68 (0.51–0.89) |
DPB1*02:02 | 64 | 6.67 | 42 | 6.21 | 0.71 | 0.93 (0.61–1.41) |
DPB1*03:01 | 27 | 2.81 | 52 | 7.69 | 5.8×10−6 | 2.88 (1.75–4.76) |
DPB1*04:01 | 85 | 8.85 | 48 | 7.10 | 0.2 | 0.79 (0.54–1.15) |
DPB1*04:02 | 37 | 3.85 | 19 | 2.81 | 0.25 | 0.72 (0.4–1.31) |
DPB1*05:01 | 362 | 37.71 | 263 | 38.91 | 0.62 | 1.05 (0.85–1.29) |
DPB1*09:01 | 15 | 1.56 | 8 | 1.18 | 0.52 | 0.75 (0.29–1.9) |
DPB1*13:01 | 43 | 4.48 | 59 | 8.73 | 0.00047 | 2.04 (1.33–3.12)) |
DPB1*14:01 | 18 | 1.88 | 11 | 1.63 | 0.71 | 0.87 (0.38–1.94) |
DPB1*17:01 | 50 | 5.21 | 18 | 2.66 | 0.011 | 0.5 (0.28–0.89) |
DPB1*19:01 | 9 | 0.94 | 7 | 1.04 | 0.84 | 1.11 (0.37–3.25) |
DPB1*21:01 | 19 | 1.98 | 9 | 1.33 | 0.32 | 0.67 (0.28–1.57) |
DPB1*35:01 | 2 | 0.21 | 7 | 1.04 | 0.026 | 5.01 (0.96–34.97) |
DPB1*135:01 | 8 | 0.83 | 10 | 1.48 | 0.22 | 1.79 (0.65–4.98) |
Others | 3.54 | 4.14 | ||||
Total | 960 | 100 | 676 | 100 |
OR = odds ratio; CI = confidence interval; nominal significance p value<0.05; Bonferroni correction for significance was calculated as p<0.0013.