Table 3. Differentiation of SSc subsets and clinical outcomes with specific HLA-DPB1 alleles.
Alleles | N (%) | N (%) | p | OR (95% CI) |
Heterozygous | ||||
ACA (+) | ACA (−) | |||
DPB1*04 | 13 (34.2) | 36 (15.4) | 0.0051 | 2.86 (1.25–6.49) |
DPB1*04:01 | 9 (23.7) | 25 (10.7) | 0.025 | 2.59 (1.01–6.55) |
DPB1*04:02 | 4 (10.5) | 11 (4.7) | 0.15 | 2.39 (0.6–8.76) |
PF (+) | PF (−) | |||
DPB1*03:01 | 39 (19.6) | 5 (6.4) | 0.0069 | 3.56 (1.27–10.73) |
Homozygous | ||||
ACA (+) | ACA (−) | |||
DPB1*05:01 | 3 (7.9) | 54 (23.1) | 0.033 | 0.29 (0.07–1.02) |
Notes: DPB1*04 only occurred in heterozygotes, heterozygous DPB1*05:01 did not show any association with SSc subsets.