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. 2014 Jan 31;9(1):e87361. doi: 10.1371/journal.pone.0087361

Figure 1. Splicing changes associated with U2AF1 S34F/Y mutation in lung adenocarcinoma and AML.

Figure 1

(A) Representation of somatic mutations in U2AF1 observed across 12 TCGA cancer types [9]. Five cancer types had no somatic mutations in U2AF1. Amino acid positions are indicated. Zn, zinc finger; UHM, U2AF homology motif. (B) JuncBASE analysis of RNA-Seq data identified 131 and 369 splicing events significantly differentially spliced in lung adenocarcinoma and AML specimens bearing U2AF1 S34F/Y mutations, respectively.