Table I.
Compositions of MO-Based LCN Containing FNS and Its Characterization Parameters
| Formulation code | MO (% w/w) | P407 (%w/w) | FNS (%w/w) | RH (%w/w) | EL (%w/w) | Distilled water (%w/w) | Particle size (nm) | PDI | Zeta potential | Entrapment efficiency (%) | Viscosity (mPa s) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| RH 0.5 | 4 | – | 0.1 | 0.5 | – | 95.4 | 165.1 ± 3.8 | 0.22 ±0.01 | −24.3 ± 0.5 | 99.4 ± 0.1 | 7.8 ± 0.7 |
| RH 1.0 | 4 | – | 0.1 | 1.0 | – | 94.9 | 162.3 ± 1.0 | 0.20 ± 0.02 | −24.6 ± 0.6 | 99.3 ± 0.1 | 8.2 ± 0.4 |
| RH 1.5 | 4 | – | 0.1 | 1.5 | – | 94.4 | 159.2 ± 1.7 | 0.15 ± 0.02 | −23.3 ± 0.9 | 99.4 ± 0.1 | 8.7 ± 0.2 |
| RH 2.0 | 4 | – | 0.1 | 2.0 | – | 93.9 | 174.2 ± 2.1 | 0.10 ± 0.01 | −23.1 ± 0.7 | 99.2 ± 0.2 | 8.8 ± 0.2 |
| RH 2.5 | 4 | – | 0.1 | 2.5 | – | 93.4 | 208.6 ± 1.9 | 0.07 ± 0.02 | −22.1 ± 0.8 | 99.3 ± 0.1 | 8.8 ± 0.2 |
| EL 1.5 | 4 | – | 0.1 | – | 1.5 | 94.4 | 153.7 ± 2.6 | 0.23 ± 0.01 | −22.8 ± 0.9 | 98.9 ± 0.1 | 7.1 ± 2.8 |
| EL 2.0 | 4 | – | 0.1 | – | 2.0 | 93.9 | 163.0 ± 1.6 | 0.19 ± 0.01 | −23.9 ± 0.6 | 98.9 ± 0.2 | 8.5 ± 0.5 |
| EL 2.5 | 4 | – | 0.1 | – | 2.5 | 93.4 | 163.4 ± 1.6 | 0.18 ± 0.01 | −22.2 ± 0.9 | 98.9 ± 0.2 | 8.8 ± 0.2 |
| EL 3.0 | 4 | – | 0.1 | – | 3.0 | 92.9 | 185.2 ± 2.2 | 0.18 ± 0.01 | −22.6 ± 0.2 | 99.0 ± 0.1 | 8.8 ± 0.7 |
| EL 4.0 | 4 | – | 0.1 | – | 4.0 | 91.9 | 243.0 ± 9.2 | 0.11 ± 0.02 | −22.0 ± 0.3 | 99.2 ± 0.1 | 9.3 ± 0.3 |
| P407 | 4 | 1.0 | 0.1 | – | – | 94.9 | 167.0 ± 1.3 | 0.20 ± 0.02 | −21.5 ± 0.4 | 99.6 ± 0.1 | 8.8 ± 0.4 |
Each value represents the mean ± SD (n = 3)
MO monoolein, P407 poloxamer 407, FNS finasteride, RH cremophor RH 40, EL cremophor EL