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Overall Solution Stress Testing Results for LY334370
| Degradation condition | AIBN radical oxidation(40°C, 7 days) | H2O2 Oxidation (room temperature, 7 days) | 0.1 N HCl (70°C, 3 days) | 0.1 N NaOH (70°C, 3 days) | Photodegradation option 1 (1.3× ICH Vis and 4× ICH UV) | Photodegradation option 2 (4.5× ICH Vis) |
|---|---|---|---|---|---|---|
| High reactivity (>10%) | 18% | 21% | 19% | |||
| Moderate reactivity (1–10%) | 2% | 6% | 5% |
Values represent percent of degradation by loss of parent based on peak area percent by LC
