Figure 4. EGFR pathway mutations affect mushroom body development.

(A) Anti-Fas II staining of wholemount brain from spi1/+. Dashed line represents the midline. Scale bar = 10 µm. (B–H) Suppression of taoEP1455 MB lobe morphology phenotype by mutations in vn and rho. Scale bar = 10 µm. (B) wt, (C) vn1/vn1 and (D) vn1/rhoiks brains have normal MB lobes. (E) taoEP1455 lacks MB α and β lobes. MB lobes in brains of (F) taoEP1455;vn1/vn1 and (G) taoEP1455;vn1/rhoiks flies. (H) Quantification of the proportion of normal MB lobes for genotypes in (C–G).