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. 2014 Jan 31;9(1):e87563. doi: 10.1371/journal.pone.0087563

Figure 6. The effects of raloxifene and miR-222-3p on RL95-2 and AN3CA cells.

Figure 6

(A) Cell viability was significantly decreased in RL95-2 and AN3CA cells treated with raloxifene. A. Raloxifene (20-µM) induced 40% inhibition of cell viability after 48 h treatment. * P<0.05. (B and C) After 24 h transfection, cells were treated with 20-µM raloxifene. At next 24 h, 48 h and 72 h, cell viability was detected by MTT assay. With miR-222-3p increasing, the cell viability of RL95-2 cells was much higher, showing less sensitivity to raloxifene. In contrast, AN3CA cells became more sensitive after miR-222-3p being inhibited. *** P<0.001.