Table 3.

Grade 3/4 drug-related toxicities observed in all cycles

Grade ¾ toxicity	Level 1 (n = 3)	Level 2 (n = 6)	Level 3 (n = 18)	Level 4 (n = 3)	All (n = 30)
Anaemia	–	3 (50 %)	3 (16.7 %)	–	6 (20.0 %)
Neutropenia	1 (33.3 %)	2 (33.3 %)	7 (38.9 %)	2 (66.7 %)	12 (40.0 %)
Thrombocytopenia	–	–	1 (5.6 %)	–	1 (3.3 %)
Febrile neutropenia	–	1 (16.7 %)	–	1 (33.3 %)	2 (6.7 %)
Diarrhoea	–	–	1 (5.6 %)	–	1 (3.3 %)
Condition aggravated	–	1 (16.7 %)	–	–	1 (3.3 %)
Fatigue	–	2 (33.3 %)	1 (5.6 %)	–	3 (10.0 %)
Hyperbilirubinaemia	–	–	1 (5.6 %)	–	1 (3.3 %)
Hypokalaemia	–	–	1 (5.6 %)	–	1 (3.3 %)
Tumour pain	–	–	–	1 (33.3 %)	1 (33.3 %)
Pulmonary haemorrhage	–	–	1 (5.6 %)	–	1 (3.3 %)
Dermatitis acneiform	–	–	1 (5.6 %)	–	1 (3.3 %)