Table 6.
Parameters associated with blood 4HNE-P and MDA levels in HF patients (multiple regression analysis).
| Parameters | β Coefficient | P |
|---|---|---|
| 4HNE-P (R2=0.5692) | ||
| Lipid profile-potential precursors | ||
| Linoleic acid | 0.0184 | 0.0031 |
| HDL-Cholesterol | 102.4 | 0.0002 |
| Disease-related parameters | ||
| NYHA | 43.4 | 0.0015 |
| History of myocardial infarction | 35.5 | 0.0122 |
| Various factors | ||
| Body mass index | 4.11 | 0.0194 |
| Total bilirubin | −2,06 | 0.0268 |
| Ratio GSH/GSSG | −0.758 | 0.0462 |
| Medication | ||
| RAS inhibitors | 63.8 | 0.0034 |
| Acute nitrate | −31.7 | 0.0034 |
| Hypoglycemic agents | −29.1 | 0.0485 |
| MDA (R2=0.4074) | ||
| Disease-related parameters | ||
| History of myocardial infarction | −244 | 0.0228 |
| Risk factors | ||
| Hypertension | 233 | 0.0286 |
| Biochemical parameters | ||
| Glucose | 48.2 | 0.0202 |
| Alkaline phosphatase | 2.57 | 0.0379 |
| Myeloperoxidase | 4.36 | 0.0005 |
| Medication | ||
| Amiodarone | −299 | 0.0151 |
Multivariate analysis was performed in HF patients only using risk factors and parameters selected for their high clinical and biochemical relevance, which are listed in the Material and Methods. A P-value<0.05 was considered statistically significant.