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. 2014 Jan 31;9(1):e88119. doi: 10.1371/journal.pone.0088119

Figure 2. Regional differences of two covariance patterns.

Figure 2

(A) Standard SPM analysis with paired t-test design for ON vs. OFF medication with 15 PD patients. (B) The PDRP derived from USA (off-medication) was subtracted from the PDRP derived from South Korea (on-medication). The resulting difference map is z-scored. Only the voxels that were reliable in permutation test were shown (p<0.05, 1,000 permutation). The topography of within-subject differences in medication status (A) was significantly correlated with between-group network differences (B) (r = 0.4228, p<0.001). Likewise, key regions of hypometabolism (e.g., M1, cingulate, cerebellum, putamen) and hypermetabolism (e.g., precuneus) were similarly shown.