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. 2014 Jan 31;9(1):e87729. doi: 10.1371/journal.pone.0087729

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© 2014 van den Heuvel et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A) ICV leptin suppressed feeding in rats on a CHOW diet and in rats on a fcHFHS diet 24 hours after ICV leptin administration. B) In the fcHFHS group leptin suppressed intake of the chow and fat component, but not sugar. Data are mean ± SEM; *P<0.05, leptin vs. vehicle.