Table 1.
Patient characteristics
|
Patient 1 |
Patient 2 |
Patient 3 |
||||
|---|---|---|---|---|---|---|
| 1st surgery | 2nd surgery | 1st surgery | 2nd surgery | 1st surgery | 2nd surgery | |
|
Age (years) |
47 |
48 |
29 |
30 |
51 |
52 |
|
Gender |
Male |
Female |
Female |
|||
|
Years of education |
10 |
10 |
19 |
|||
|
Tumor entity |
glioblastoma WHO grade IV |
glioblastoma WHO grade IV |
astrocytoma WHO grade III |
astrocytoma WHO grade III |
glioblastoma WHO grade IV |
glioblastoma WHO grade IV |
|
Tumor location |
opIFG |
opIFG |
anG |
anG |
opIFG |
opIFG |
|
Tumor volume (cm
3
) |
20.6 |
21.7 |
65.5 |
6.7 |
195.4 |
45.3 |
|
Time between surgeries (months) |
7 |
15 |
10 |
|||
|
Adjuvant therapy before surgery |
none |
RTx & TMZ |
none |
TMZ |
none |
RTx & TMZ |
|
Correct baseline pictures (out of 131) |
104 (79%) |
102 (78%) |
101 (77%) |
98 (75%) |
81 (62%) |
98 (75%) |
|
RMT (% output) |
30 |
30 |
34 |
35 |
28 |
33 |
|
Mapping intensity (% of MT) |
110 |
100 |
100 |
100 |
100 |
100 |
|
Most comfortable frequency |
5 Hz/5 |
7 Hz/5 |
5 Hz/5 |
5 Hz/5 |
5 Hz/5 |
7 Hz/7 |
|
Pain during stimulation (VAS): convexity |
3 |
4 |
2 |
4 |
1 |
7 |
|
Pain during stimulation (VAS): temporal |
6 |
7 |
7 |
6 |
4 |
7 |
|
Number of errors left hemisphere |
119 |
62 |
151 |
135 |
151 |
83 |
|
Number of stimulations left hemisphere |
750 |
390 |
675 |
405 |
641 |
258 |
|
Error rate left hemisphere |
15.9% |
15.9% |
22.4% |
33.3% |
23.6% |
32.2% |
|
no response |
3.3% |
6.2% |
13.3% |
8.6% |
2.8% |
8.9% |
|
performance |
2.5% |
1.3% |
2.5% |
7.4% |
8.6% |
9.3% |
|
hesitation |
9.7% |
7.4% |
5.6% |
16.0% |
9.5% |
13.6% |
|
neologism |
0.3% |
0.0% |
0.7% |
0.7% |
2.7% |
0.0% |
|
phonological error |
0.0% |
0.5% |
0.0% |
0.0% |
0.0% |
0.0% |
|
semantic error |
0.0% |
0.5% |
0.1% |
0.5% |
0.0% |
0.4% |
|
Preoperative aphasia |
0 |
0 |
0 |
1A |
1A |
2A |
|
Postoperative aphasia (5th day after surgery) |
0 |
0 |
1B |
1A |
2A |
2A |
|
Postoperative aphasia (3 months after surgery) |
0 |
0 |
0 |
1A |
0 |
2A |
| Extent of tumor resection | Complete | Complete | Complete | Complete | Complete | Partial |
This table shows the characteristics of all patients including pre- and intraoperative findings. Aphasia scale: 0 (no aphasia), 1 (mild aphasia with unremarkable communication), 2 (slightly impaired communication), 3 points (severe grade of aphasia); motoric aphasia = A, sensory aphasia = B. Moreover, the extent of tumor resection is presented. RMT = resting motor threshold (% stimulator output), VAS = visual analogue scale, RTx = radiotherapy, TMZ = Temozolomide.