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. 2014 Jan 29;13:36. doi: 10.1186/1475-2875-13-36

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Copyright © 2014 Zhao et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Final population pharmacokinetic (PK) model: predicted and observed (A) serum azithromycin (AZ) and (B) plasma chloroquine (CQ) concentrations versus time after last dose relative to sampling time. Figure 1 shows (A) serum AZ and (B) plasma CQ measured and predicted concentrations in various age groups. Black filled circles represent observed data points and red open circles are population predicted values for the final PK model. Good concordance between observed and predicted data points is evident.