Table 2.
Parameter estimates for final population PK model: azithromycin in serum and chloroquine in plasma
|
Parameter (units) |
PK parameter mean (%RSE) |
Inter-individual variability %CV (%RSE) |
PK parameter mean (%RSE) |
Inter-individual variability %CV (%RSE) |
|---|---|---|---|---|
| Azithromycin | Chloroquine | |||
| CL/F (L/h) |
100 (6.1) |
31.3 (17.6) |
59.1 (2.3) |
30.5 (12.2) |
| Normalized for weight |
0.75 FIXED |
|
0.75 FIXED |
|
| V1/F (L) |
186 (22.4) |
113 (31.8) |
2,870 (4.3) |
46.6 (15.7) |
| Normalized for weight |
1 FIXED |
CL:V1 covariance 0.28 |
1 FIXED |
CL:V1 covariance 0.72 |
| Ka (1/h) |
0.259 (10.2) |
NE |
6.12 (29.4) |
NE |
| Q2/F (L/h) |
180 (8.2) |
NE |
61.4 (11.3) |
NE |
| Normalized for weight |
0.75 FIXED |
|
0.75 FIXED |
|
| V2/F (L) |
2,890 (4.8) |
NE |
1,890 (4.9) |
NE |
| Normalized for weight |
1 FIXED |
|
1 FIXED |
|
| LAG (h) |
NE |
NE |
0.387 (6.7) |
NE |
| Q3/F (L/h) |
10.6 (19.0) |
NE |
NE |
NE |
| V3/F (L) |
2,610 (46.7) |
NE |
NE |
NE |
| Residual error (%RSE) | 0.406 (2.4) | NE | 0.249 (2.6) | NE |
%CV, Percent coefficient of variation; %RSE, Relative standard error expressed as percentage; CL/F, Clearance normalized for bioavailability; IIV, Inter-individual variability; Ka, Absorption rate constant; LAG, Lag time; NE, Not estimated; PK, Pharmacokinetics; Q2/F, Inter-compartmental clearance from central to first peripheral compartment; Q3/F, Inter-compartmental clearance from central to second peripheral compartment; V1/F, Volume of distribution of the central compartment; V2/F, Volume of distribution of first peripheral compartment; V3/F, Volume of distribution of second peripheral compartment.