Table 4.
Association of serum PFOS and PFOA levels to CRC cancer diagnosis in adults ≥ 21 years of age, stratifed by BMI
| |
Obese (BMI ≥ 30, N = 66 cases) |
Non-obese (BMI < 30, N = 142 cases) |
P for interaction | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |
Cases | Controls | Odds ratio |
95% CI |
P | Cases | Controls | Odds ratio |
95% CI |
P | |||
| Lower | Upper | Lower | Upper | ||||||||||
|
PFOS quartiles
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| First (reference) |
27 |
4273 |
1.00 |
|
|
|
52 |
7384 |
1.00 |
|
|
|
0.65 |
| Second |
10 |
4223 |
0.26 |
0.13 |
0.55 |
0.0004 |
29 |
7565 |
0.42 |
0.26 |
0.67 |
0.0002 |
|
| Third |
14 |
4205 |
0.30 |
0.16 |
0.58 |
0.0004 |
28 |
7633 |
0.30 |
0.19 |
0.49 |
<0.00001 |
|
| Fourth |
15 |
4086 |
0.23 |
0.12 |
0.44 |
<0.00001 |
33 |
7782 |
0.25 |
0.16 |
0.39 |
<0.00001 |
|
|
Test for trend |
|
|
|
|
|
<0.00001 |
|
|
|
|
|
<0.00001 |
|
|
PFOA quartiles
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| First (reference) |
16 |
4395 |
1.00 |
|
|
|
42 |
7193 |
1.00 |
|
|
|
0.09 |
| Second |
12 |
4452 |
0.62 |
0.29 |
1.32 |
0.22 |
24 |
7536 |
0.44 |
0.26 |
0.73 |
0.002 |
|
| Third |
16 |
4100 |
0.69 |
0.34 |
1.39 |
0.30 |
33 |
7696 |
0.45 |
0.28 |
0.72 |
0.001 |
|
| Fourth |
22 |
3840 |
0.87 |
0.45 |
1.67 |
0.67 |
43 |
7939 |
0.52 |
0.34 |
0.80 |
0.003 |
|
| Test for trend | 0.57 | 0.001 | |||||||||||