Table 5.
Association of serum PFOA and PFOS levels to CRC diagnosis in adults 21+years, stratified by year of diagnosis
| |
Diagnosis in 2000 or later (N=94 cases)** |
Diagnosis before 2000 (N=99 cases)** |
P for interaction | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |
Cases | Controls | Odds ratio |
95% CI |
P | Cases | Controls | Odds ratio |
95% CI |
P | |||
| Lower | Upper | Lower | Upper | ||||||||||
|
PFOS quartiles
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| First (reference) |
50 |
11657 |
1.00 |
|
|
|
27 |
11657 |
1.00 |
|
|
|
0.04 |
| Second |
15 |
11788 |
0.22 |
0.12 |
0.39 |
<0.00001 |
20 |
11788 |
0.56 |
0.31 |
1.00 |
0.05 |
|
| Third |
16 |
11838 |
0.18 |
0.10 |
0.31 |
<0.00001 |
23 |
11838 |
0.49 |
0.28 |
0.87 |
0.015 |
|
| Fourth |
13 |
11868 |
0.10 |
0.05 |
0.19 |
<0.00001 |
29 |
11868 |
0.44 |
0.25 |
0.74 |
0.002 |
|
|
Test for trend |
|
|
|
|
|
<0.00001 |
|
|
|
|
|
0.015 |
|
|
PFOA quartiles |
|
|
|
|
|
|
|
|
|
|
|
|
0.02 |
| First (reference) |
35 |
11588 |
1.00 |
|
|
|
21 |
11588 |
1.00 |
|
|
|
|
| Second |
14 |
11988 |
0.32 |
0.17 |
0.59 |
0.0003 |
18 |
11988 |
0.68 |
0.36 |
1.27 |
0.23 |
|
| Third |
19 |
11796 |
0.34 |
0.19 |
0.59 |
0.0002 |
25 |
11796 |
0.71 |
0.39 |
1.28 |
0.26 |
|
| Fourth |
26 |
11779 |
0.41 |
0.25 |
0.68 |
0.0007 |
35 |
11779 |
0.91 |
0.53 |
1.58 |
0.74 |
|
| Test for trend | 0.00004 | 0.50 | |||||||||||
Table 3-5. Abbreviations: BMI body mass index (kg/m2), CI Confidence interval, CRC colorectal cancer, PFOA perfluorooctanoate, PFOS perfluorooctanesulfonic acid.
* All analyses adjusted for sociodemographic and lifestyle factors, BMI, menopausal status, and comorbidity. Sociodemographics include age, race/ethnicity, gender, education, income, marital status, and employment status; lifestyle factors include smoking status; current alcohol consumption; regular exercise program; comorbidity includes physician diagnosis of comorbid conditions (heart, kidney, liver, immune, connective tissue, and thyroid disease, stroke, hypertension, dyslipidemia, diabetes, chronic obstructive pulmonary disease, or asthma) and current treatment for hypertension or hyperlipidemia.
**Information on year of diagnosis missing for 15 CRC cases.