Figure 2.
Effect of eritoran tetrasodium on corneal infiltrates. Corneas of C57BL/6 mice were abraded and treated with eritoran tetrasodium or placebo before LPS or Pam3Cys stimulation. After 24 hours, which is the peak of neutrophil infiltration, corneas were examined by in vivo confocal microscopy. Representative images of the central corneal stroma reveal cellular infiltration in LPS-treated corneas either alone or with placebo, but not in eritoran tetrasodium-treated corneas. In contrast, the cellular infiltrate was present in antagonist-treated and placebo-treated corneas stimulated with Pam3Cys.
