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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2008 Oct 20;50(3):1247–1254. doi: 10.1167/iovs.08-2628

Figure 4.

Figure 4

Comparison of eritoran tetrasodium given before and after LPS-induced corneal inflammation. Mouse corneas were abraded as described in the legend to Figure 1. (A, B) Corneas were treated with 2 µL of 1.1 mg/mL eritoran tetrasodium or placebo either before LPS (prior), at the same time as LPS (same), or 1 hour after LPS stimulation (post). After 24 hours, neutrophil infiltration and corneal haze were measured as before. *Significant differences (P < 0.001) for prior and same treated with eritoran tetrasodium versus placebo; P < 0.05 for post treatment with eritoran versus placebo. (C, D) The dose–response of antagonist given as a therapeutic (posttreatment) 1 hour after LPS stimulation. These experiments were repeated three times with similar results. Tr, trauma control; 0: LPS only.