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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2008 Oct 20;50(3):1247–1254. doi: 10.1167/iovs.08-2628

Figure 7.

Figure 7

Effect of eritoran tetrasodium on corneal inflammation induced by antibiotic-killed P. aeruginosa. P. aeruginosa strain ATCC 19660 was killed by 30 minutes incubation with 0.3% tobramycin, and 1 × 107 bacteria were added to the abraded corneal surface of C57BL/6, TLR4−/−, and MD-2−/− mice, and a 2 mm diameter punch from a silicon hydrogel was added. Corneas were treated with 2.2 µg eritoran tetrasodium in 2 µL H2O or with placebo. After 24 hours, neutrophil infiltration, and corneal thickness and haze were measured as before. Data were analyzed by ANOVA and statistically significant differences (*P < 0.05; **P < 0.001) were noted for all parameters between C57BL/6 mice compared with TLR4−/− and MD-2−/− mice (A), and between eritoran tetrasodium compared with placebo. These data are the mean ± SD of five mice per group, and the experiments were repeated twice with similar results.