Table 4.
Combined effect of GSTM1/GSTA1 polymorphisms as predictors for overall and cardiovascular mortality as well as death of myocardial infarction and cerebral vascular insult among 199 ESRD patients after a median follow-up time of 8 yrs by Cox proportional hazards regression models
|
Model 1
a
|
Model 2
b
|
Model 3
c
|
|||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value |
|
Risk for overall mortality comparing combined
GSTM1*0/0 and GSTA1*A/A
homozygotes to carriers of at least one
GSTM1
-active and/or
GSTA1*B
allele | |||||
| 1.86 (1.03-3.36) |
0.039 |
1.98 (1.10-3.58) |
0.023 |
2.08 (1.13-3.83) |
0.019 |
|
Risk for cardiovascular mortality comparing combined
GSTM1*0/0
and
GSTA1*A/A
homozygotes to carriers of at least one
GSTM1-
active and/or
GSTA1*B
allele | |||||
| 1.88 (0.93-3.82) |
0.078 |
1.92 (0.95-3.91) |
0.070 |
2.06 (0.98-4.34) |
0.057 |
|
Risk for death of MI comparing combined
GSTM1*0/0
and
GSTA1*A/A
homozygotes to carriers of at least one
GSTM1-
active and/or
GSTA1*B
allele | |||||
| 2.23 (0.86-5.80) |
0.099 |
2.25 (0.86-5.89) |
0.098 |
2.27 (0.81-6.38) |
0.121 |
|
Risk for death of CVI comparing combined
GSTM1*0/0
and
GSTA1*A/A
homozygotes to carriers of at least one
GSTM1
active and/or
GSTA1*B
allele | |||||
| 3.35 (1.22-9.21) | 0.019 | 3.55 (1.28-9.84) | 0.015 | 4.38 (1.50-12.75) | 0.007 |
Abbreviations: CI Confidence Interval, HR Hazard Ratio, CVI Cerebral Vascular Insult, MI Myocardial Infarction.
aAdjusted for age and gender.
bAdjusted for the covariates in Model 1 plus an additional adjustment for smoking status.
cAdjusted for the covariates in Model 2 plus an additional adjustment for diabetes and cholesterol level.